Creatine was determined in 1832 when Michel Eugène Chevreul isolated it from the basified water-extract of skeletal muscle. He later named the crystallized precipitate after the Greek word for meat, κρέας (kreas).Apart from its pharmacological effects, creatine content (as a percentage of unrefined protein) can be utilized as an indicator of meat quality.In solution, creatine is in equilibrium with creatinine. Creatine is a derivative of the guanidinium cation.
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